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Literature summary extracted from

  • Jordan, P.M.; Berry, A.
    Preuroporphyrinogen, a universal intermediate in the biosynthesis of uroporphyrinogen III (1980), FEBS Lett., 112, 86-88.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.61 porphobilinogen Cereibacter sphaeroides
-
 ?
-
 ?
2.5.1.61 porphobilinogen Cereibacter sphaeroides NCIB 8253
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.61 Cereibacter sphaeroides
-
 N.C.I.B. 8253
-
2.5.1.61 Cereibacter sphaeroides NCIB 8253
-
 N.C.I.B. 8253
-
4.2.1.75 Cereibacter sphaeroides
-
-
-
4.2.1.75 Gallus gallus
-
-
-
4.2.1.75 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Cereibacter sphaeroides uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen in the presence of uroporphyrinogen III cosynthase, EC 4.2.1.75 Cereibacter sphaeroides NCIB 8253 uroporphyrinogen III + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Cereibacter sphaeroides hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 4 porphobilinogen + H2O
-
 Cereibacter sphaeroides NCIB 8253 hydroxylmethylbilane + 4 NH3
-
 ?
2.5.1.61 porphobilinogen
-
 Cereibacter sphaeroides ?
-
 ?
2.5.1.61 porphobilinogen
-
 Cereibacter sphaeroides NCIB 8253 ?
-
 ?
4.2.1.75 Preuroporphyrinogen
-
 Gallus gallus Uroporphyrinogen III
-
 ?
4.2.1.75 Preuroporphyrinogen
-
 Saccharomyces cerevisiae Uroporphyrinogen III
-
 ?
4.2.1.75 Preuroporphyrinogen
-
 Cereibacter sphaeroides Uroporphyrinogen III
-
 ?
4.2.1.75 Preuroporphyrinogen
-
 Cereibacter sphaeroides NCIB 8253 Uroporphyrinogen III
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.61 porphobilinogen deaminase
-
 Cereibacter sphaeroides
2.5.1.61 preuroporphyrinogen synthetase
-
 Cereibacter sphaeroides

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.2.1.75 7.4
-
-
 Gallus gallus
4.2.1.75 8.2
-
 due to instability of preuroporphyrinogen at lower pH enzyme assay with preuroporphyrinogen at Gallus gallus
4.2.1.75 8.2
-
 due to instability of preuroporphyrinogen at lower pH enzyme assay with preuroporphyrinogen at Saccharomyces cerevisiae
4.2.1.75 8.2
-
 due to instability of preuroporphyrinogen at lower pH enzyme assay with preuroporphyrinogen at Cereibacter sphaeroides